Cefuroxime Sodium Impurity A (EP)

Cefuroxime Sodium Impurity A (EP) - Names and Identifiers

Name	[6R-[6alpha,7beta(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms	Einecs 260-086-2 Cefuroxime sodium impurity A Cefuroxime Sodium EP Impurity A Cefuroxime Sodium Impurity A (EP) (6R)-7α-[[2-Furanyl(methoxyimino)acetyl]amino]-3-hydroxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid [6R-[6alpha,7beta(Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (6R-(6alpha,7beta(Z)))-7-(2-Furyl(methoxyimino)acetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid (6R,7R)-7-[[(2Z)-2-(2-Furanyl)-2-(MethoxyiMino)acetyl]aMino]-3-(hydroxyMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
CAS	56271-94-4
EINECS	2600862

Cefuroxime Sodium Impurity A (EP) - Physico-chemical Properties

Molecular Formula	C15H15N3O7S
Molar Mass	381.3605
Density	1.71±0.1 g/cm3(Predicted)
pKa	2.75±0.50(Predicted)
Storage Condition	-20°C Freezer, Under Inert Atmosphere

Cefuroxime Sodium Impurity A (EP) - Introduction

Cefuroxime sodium EP is an antibiotic, and its impurity A refers to one of the main impurities of cefuroxime sodium. The following is about [6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0] Introduction of the nature, use, preparation method and safety information of oct-2-ene-2-carboxylic acid:

1. Nature:
[6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is a chemical substance whose chemical structure is similar to cefuroxime sodium. It is a solid that exists at room temperature and has a certain solubility. [6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is usually an impurity, and its presence will affect the purity and quality of cefuroxime sodium.

2. Use:
[6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is mainly used as an analytical standard for Cefuroxime sodium to test and analyze the quality of cefuroxime sodium. It plays an important role in drug research, production and quality control.

3. Preparation method:
[6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl) the preparation method of-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is generally produced by a side reaction in the synthesis process of cefuroxime sodium. In the process of preparing cefuroxime sodium, some by-products or impurities sometimes appear, one of which is impurity A. Impurity A is usually obtained by an elaborate purification process.

4. Safety Information:
About [6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic the security information of acid, you need to pay attention to the following points:
- [6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid is limited to laboratory use and is not suitable for human or animal treatment.
-use should follow the safety procedures, avoid direct contact with eyes, skin or mouth.
-In processing [6R-[6alpha,7Beta (Z)]]-7-[2-furyl(methoxyimino)acetamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0] When oct-2-ene-2-carboxylic acid, take appropriate personal protective measures, such as wearing gloves, masks and goggles.
-Waste should be disposed of in accordance with national and local regulations to ensure that it does not pollute the environment.

Last Update：2024-04-09 19:05:02